Elevated c-Src and c-Yes expression in malignant skin cancers.

Research paper by Jang Hyun JH Lee, Jae-Kyung JK Pyon, Dong Wook DW Kim, Sang Han SH Lee, Hae Seon HS Nam, Chul Han CH Kim, Sang Gue SG Kang, Yoon Jin YJ Lee, Mi Youn MY Park, Dong Jun DJ Jeong, Moon Kyun MK Cho

Indexed on: 28 Aug '10Published on: 28 Aug '10Published in: Journal of experimental & clinical cancer research : CR


Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hyper-activated in many human epithelial cancers. However, only a few studies have attempted to define the expression and role of c-Src and c-Yes in cutaneous carcinomas.To investigate the expression of c-Src and c-Yes in cutaneous carcinomas to include malignant melanoma (MM), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).We examined 6 normal skin tissues and 18 malignant skin tumor tissues using western blotting for the expression of c-Src and c-Yes. In another set, 16 specimens of MM, 16 SCCs and 16 BCCs were analyzed for the expression of c-Src and c-Yes using immunohistochemical staining.Western blotting showed that c-Src was expressed in all malignant skin tumors, but not in normal skin, while c-Yes was expressed in MM and SCC, but not in BCC and normal skin. Immunohistochemical staining results of c-Src and c-Yes in MM, SCC, and BCC mirrored those of the western blot analysis.c-Src, rather than c-Yes, plays a key role in the proliferation and progression of malignant skin cancers.