Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-D-xylofuranose.

Research paper by Rajiv R Trivedi, E E Rami Reddy, Ch Ch Kiran Kumar, B B Sridhar, K K Pranay Kumar, M M Srinivasa Rao

Indexed on: 07 Jun '11Published on: 07 Jun '11Published in: Bioorganic & Medicinal Chemistry Letters


A simple and efficient synthetic approach toward a series of chiral aryl boronate esters, starting from D-xylose, as anti-microbial agents, is described herein. Minimum inhibitory concentration and zone of inhibition revealed that these derivatives exhibit potent anti-bacterial and anti-fungal properties. Herein, we report the first anti-microbial activity of this class of compounds. All products have been characterized by NMR ((1)H, (13)C and (11)B), IR, elemental and mass spectral study.