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Efficacy of liposomal amphotericin B combined with gamma interferon or granulocyte-macrophage colony-stimulating factor for treatment of systemic zygomycosis in mice.

Research paper by M Mar MM Rodríguez, Enrique E Calvo, Marçal M Mariné, F Javier FJ Pastor, Joan J Fernandez-Ballart, Josep J Guarro

Indexed on: 20 May '09Published on: 20 May '09Published in: Antimicrobial agents and chemotherapy



Abstract

Granulocyte-macrophage colony-stimulating factor enhanced the efficacy of liposomal amphotericin B (LAMB) in a murine model of disseminated infection by Rhizopus oryzae, significantly prolonging survival and reducing tissue burden. The use of gamma interferon (IFN-gamma) alone was ineffective, and IFN-gamma combined with LAMB did not improve the results obtained with LAMB alone.