Efficacy of heparin loading during an 18F-FDG PET/CT examination to search for cardiac sarcoidosis activity.

Research paper by Kimiteru K Ito, Miyako M Morooka, Osamu O Okazaki, Ryogo R Minaminoto, Kazuo K Kubota, Michiaki M Hiroe

Indexed on: 22 Jan '13Published on: 22 Jan '13Published in: Clinical nuclear medicine


A 65-year-old woman with a complete atrioventricular block was diagnosed as having cardiac sarcoidosis. (18)F-FDG PET/CT imaging without unfractionated heparin loading revealed systemic abnormal uptake indicating sarcoidosis. However, the cardiac lesions were vague because of the physiological FDG uptake. One month later, (18)F-FDG PET/CT using heparin loading was performed to evaluate the lesion activity prior to the start of steroid administration. (18)F-FDG PET/CT imaging with heparin loading showed the cardiac lesions more clearly and suppressed the FDG uptake in normal myocardium. Heparin loading during FDG PET/CT may be useful for detecting cardiac involvement in patients with cardiac sarcoidosis.