Quantcast

Efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis in vitro and in an experimental model of actinomycetoma in BALB/c mice.

Research paper by Brenda Edith BE Chacon-Moreno, Oliverio O Welsh, Norma N Cavazos-Rocha, Maria M de la Luz Salazar-Cavazos, Hector Gerardo HG Garza-Lozano, Salvador S Said-Fernandez, Jorge J Ocampo-Candiani, Lucio L Vera-Cabrera

Indexed on: 15 Oct '08Published on: 15 Oct '08Published in: Antimicrobial agents and chemotherapy



Abstract

The efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis was evaluated by applying 25 mg of each drug/kg subcutaneously every 8 h in BALB/c mice infected with N. brasiliensis. A statistically significant difference was observed only with moxifloxacin. A moxifloxacin-trimethoprim-sulfamethoxazole combination was as active as when each compound was used alone.