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Efficacy of 10% Potassium Hydroxide Solution Versus 10% Salicylic Acid Ointment in Treatment of Molluscum Contagiosum - the Low - Cost Dermatologic Therapy in Vietnam.

Research paper by Sau Nguyen SN Huu, Minh Nguyen MN Quang, Thuong Nguyen TN Van, Kiem Pham KP Cao, Hien Do Thi HDT Thu, Lan Pham LP Thi, Van Tran VT Cam, My Le ML Huyen, Khang Tran KT Hau, Marco M Gandolfi, Francesca F Satolli, Claudio C Feliciani, Michael M Tirant, Aleksandra A Vojvodic, Torello T Lotti

Indexed on: 13 Feb '19Published on: 13 Feb '19Published in: Open Access Macedonian Journal of Medical Sciences



Abstract

Molluscum contagiosum is a common viral disease primarily affecting children. The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum. Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KOH solution and 31 patients treated with 10% salicylic pomade. The evaluation was based on the complete clearance of lesions, side effects and complications of the drug. The clearance of all lesions after 2, 4, 6, 8 weeks of treatment in both groups were 7.7%; 23.1%; 53.8%; 79.5% and 0%; 3.2%, 9.7% 22.6%, respectively (p < 0.05). Side effects were seen in both groups include burning (76.9% versus 19.4%; p < 0.05); redness (59% versus 14%; p < 0.01); desquamation (12.8% versus 19.3%; p < 0.05). The efficacy of KOH solution in the treatment of MC was better than that of salicylic pomade and both products are safe, effective, and easy to apply at home.