Effects of Acetyl-l-Carnitine and Myo-Inositol on High-Energy Phosphate and Membrane Phospholipid Metabolism in Zebra Fish: A 31P-NMR-Spectroscopy Study

Research paper by J. Levine, K. Panchalingam, R. J. McClure, S. Gershon, J. W. Pettegrew

Indexed on: 01 May '03Published on: 01 May '03Published in: Neurochemical Research


Acetyl-l-carnitine (ALCAR) and myo-inositol are reported to enhance motor activity in animal models; modulate membrane phospholipid metabolism (ALCAR and myo-inositol) and high-energy phosphate metabolism (ALCAR) back to normal; and be effective treatments of major depression in humans. Fish in general and zebra fish in particular present unique animal models for the in vivo study of high-energy phosphate and membrane phospholipid metabolism by noninvasive in vivo 31P NMR. This 31P NMR study of free-swimming zebra fish showed that both ALCAR and myo-inositol decreased levels of phosphodiesters and inorganic orthophosphate and increased levels of PCr in the fish. These findings demonstrate both ALCAR and myo-inositol modulate membrane phospholipid and high-energy phosphate metabolism in free-swimming zebra fish.