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Effect of endemic fluorosis on hematological parameters.

Research paper by Ismail Hakki IH Ersoy, E Guçhan EG Alanoglu, Banu Kale BK Koroglu, Simge S Varol, Selahaddin S Akcay, Yunus Y Ugan, Sıddıka S Ersoy, Mehmet Numan MN Tamer

Indexed on: 08 Jan '10Published on: 08 Jan '10Published in: Biological Trace Element Research



Abstract

Although so many studies exist on effect of fluoride on hematological parameters in experimental animals, a few studies have been conducted to investigate the effects of chronic fluorosis on hematological parameters in humans' subjects with endemic fluorosis. So we aimed to determine the hematological parameters in patients with endemic fluorosis. The study group consisted of 60 patients with endemic fluorosis (27 females, 33 males, and mean age 33.4 ± 9.6 years). An age-, gender-, and body mass index-matched control group was composed of 34 healthy volunteers (11 females, 23 males with a mean age 32.6 ± 5.6 years). Urine fluoride levels of fluorosis patients were significantly higher than control subjects as expected (0.42 ± 0.09 vs 1.92 ± 0.14 mg/l, respectively; P < 0.001). There were no statistically significant differences between the fluorosis group and control group with respect to hematological parameters (complete blood count and ferritin). We concluded that chronic fluorosis has no effect on hematological parameters in patients with endemic fluorosis.