Effect of amniotic membrane after laser-assisted subepithelial keratectomy on epithelial healing: clinical and refractive outcomes.

Research paper by Hyung Keun HK Lee, Jin Kook JK Kim, Sung Soo SS Kim, Eung Kweon EK Kim, Kwang One KO Kim, In Sik IS Lee, Gong Je GJ Seong

Indexed on: 20 Mar '04Published on: 20 Mar '04Published in: Journal of Cataract & Refractive Surgery


To evaluate the effect of an amniotic membrane (AM) on reepithelialization time, corneal haze, and postoperative visual and refractive outcomes after laser-assisted subepithelial keratectomy (LASEK) for myopia and myopic astigmatism.Department of Ophthalmology, Yonsei University College of Medicine, and Balgeunsesang Ophthalmology Clinic, Seoul, Korea.One hundred fifty-two eyes of 84 patients with myopia or myopic astigmatism were prospectively evaluated for 6 months after LASEK. An AM was placed as a strip on the inferior limbus in 94 eyes of 54 patients after LASEK; 58 eyes of 30 patients served as the control group. Postoperative epithelial healing time, uncorrected visual acuity (UCVA), best corrected visual acuity, remaining refractive error, and corneal haze were examined.The reepithelialization time was shorter in the AM group (2.40 days +/- 0.94 [SD]) than in the control group (3.90 +/- 0.97 days) (P<.001). At 6 months, 86 eyes (91.5%) in the AM group had a UCVA of 20/25 or better and 90 eyes (95.7%) had a UCVA of 20/40 or better; 48 eyes (82.8%) and 53 eyes (91.4%) in the control group had a UCVA of 20/25 or better and 20/40 or better, respectively. The mean spherical equivalent in the AM group was -0.48 +/- 0.54 diopter (D) and in the control group, -0.94 +/- 0.60 D (P<.001). The corneal haze was significantly less in the AM group than in the control group (P<.001).Amniotic membrane use after LASEK induced rapid epithelial healing with more favorable visual and refractive outcomes and lower corneal haze scores than conventional LASEK.