Effect of 3,5-Dicarbomethoxyphenylbiguanide on Free Radical Homeostasis in Rats with Experimental Myocarditis

Research paper by E. S. Tanigina, A. V. Semenikhina, T. N. Popova, L. V. Matasova, E. D. Kryl’skiy

Indexed on: 02 Dec '12Published on: 02 Dec '12Published in: Bulletin of Experimental Biology and Medicine


Administration of 3,5-dicarbomethoxyphenylbiguanide to rats with experimental epinephrineinduced myocarditis was followed by a decrease in activity of marker enzymes for cardiomyocyte cytolysis in the blood serum. This agent also decreased the intensity of free radical processes and had a normalizing effect on aconitase activity in the heart and blood serum of rats with myocarditis.