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Early atherosclerosis in ulcerative colitis: cross-sectional case-control study.

Research paper by Samit S SS Jain, Dharmesh K DK Shah, Pravir A PA Gambhire, Ravi U RU Varma, Qais Q QQ Contractor, Pravin M PM Rathi

Indexed on: 30 Oct '15Published on: 30 Oct '15Published in: Journal of Digestive Diseases



Abstract

To study the extent of early atherosclerosis in ulcerative colitis (UC) patients by measuring carotid intima-media thickness (CIMT) and the correlation between CIMT, serum homocysteine level and homeostasis model assessment-insulin resistance (HOMA-IR) in UC.We studied 60 UC patients and 60 healthy controls. Individuals with risk factors for atherosclerosis were excluded from the study. Fasting blood glucose, lipid profile, HOMA-IR, erythrocyte sedimentation rate (ESR), serum vitamin B12 and homocysteine levels were measured in all participants. CIMT was measured using a B-mode duplex imaging study.UC patients had significantly higher CIMT than controls (P < 0.05). ESR, fasting insulin, HOMA-IR and serum homocysteine levels were also significantly higher in UC patients (P < 0.05). Pearson's correlation coefficient showed significant correlations between: (i) CIMT and patients' age, duration of UC, HOMA-IR, and homocysteine level (P < 0.05); (ii) serum homocysteine and duration of UC, fasting insulin level, HOMA-IR and CIMT (P < 0.01); (iii) HOMA-IR and age, duration of UC, serum homocysteine and CIMT (P < 0.01). Multi-regression models showed that serum homocysteine affects CIMT and duration of UC independently, whereas participants' age and duration of UC affects HOMA-IR independently.Higher CIMT might indicate subclinical atherosclerosis in UC patients. Patients' age, duration of UC, HOMA-IR and homocysteine levels are important factors associated with increased CIMT.