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Dyschromatosis universalis hereditaria in three siblings

Research paper by YJ Bhat, I Latief, I Hassan

Indexed on: 15 Jan '17Published on: 27 Dec '16Published in: Pigment International



Abstract

YJ Bhat, I Latief, I Hassan Pigment International 2016 3(2):108-110 Dyschromatosis universalis hereditaria (DUH) is a rare genodermatosis, which has been reported most often from Japan. The etiology of this disorder is not yet known. DUH is characterized by mixtures of hyperpigmented- and hypopigmented macules all over the body. Skin lesions are usually present in the first years of life. The trunk and extremities are the dominant sites. We report this pigmentary disorder in three siblings, two females and one male. These siblings presented with hypo- and hyperpigmented macules arranged in a reticulate pattern over trunk, dorsal and ventral aspects of legs and arms, and dorsa of both hands and feet. The biopsy findings were also consistent with DUH. Autosomal dominant pattern of inheritance was seen as one of the parents was also affected. There was no systemic involvement.