Dual responsiveness of a tunable thermo-sensitive polypeptide.

Research paper by Caroline M CM Chopko, Erika L EL Lowden, Amanda C AC Engler, Linda G LG Griffith, Paula T PT Hammond

Indexed on: 19 Jun '12Published on: 19 Jun '12Published in: ACS Macro Letters


The temperature and pH dependent solubility of poly(γ-propargyl L-glutamate) (PPLG) functionalized through copper catalyzed 1,3 cycloaddition reaction between an alkyne and azide can be tuned with precision over a broad range of conditions by varying the ratio of substitution of short oligo ethylene glycol and diisopropylamine side groups.