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Drug-induced liver injury from initial dose of infliximab.

Research paper by Fong-Kuei F FK Cheng, Edward E EE Bridges, John D JD Betteridge

Indexed on: 03 Jun '15Published on: 03 Jun '15Published in: Military medicine



Abstract

Acute hepatotoxicity secondary to infliximab can occur with or without autoimmunity. A growing body of infliximab drug-induced liver injury cases without autoantibody formation is emerging. Nearly all other reported cases occur after at least three doses. This suggests infliximab may have a direct cytotoxic effect on the liver. We report a case of drug-induced liver injury resulting after an initial dose of infliximab.