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Doxofylline: a "novofylline".

Research paper by Clive P CP Page

Indexed on: 13 Apr '10Published on: 13 Apr '10Published in: Pulmonary Pharmacology and Therapeutics



Abstract

Xanthines such as theophylline have been used in the treatment of lung diseases since the early 1900's, but have a major drawback of a very narrow therapeutic window and many drug/drug interactions. With the increasing availability of other classes of drugs, this has limited the use of xanthines. Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as theophylline and the evidence supporting the effects of doxofylline in the treatment of lung diseases is discussed.