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DNA Methylation of ADME Genes

Research paper by P Fisel, E Schaeffeler, M Schwab

Indexed on: 09 Mar '16Published on: 19 Feb '16Published in: Clinical Pharmacology & Therapeutics



Abstract

The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to interindividual variability in drug response. Epigenetic mechanisms include DNA methylation, histone modifications, and miRNAs. This review systematically outlines the influence of DNA methylation on ADME gene expression and highlights the consequences for interindividual variability in drug response or drug‐induced toxicity and the implications for personalized medicine.