Disseminated cryptococcosis

Research paper by Meenakshi Bothra, Prakash Selvaperumal, Madhulika Kabra, Prashant Joshi

Indexed on: 22 Mar '14Published on: 22 Mar '14Published in: Indian Pediatrics


Fungal infections, especially in immunocompetent children are uncommon causes of fever of unknown origin.A 5-year-old boy with prolonged fever and no evidence of immunosuppression.Ultrasound-guided retroperitoneal lymph node biopsy showed granulomas and intracytoplamic fungal yeasts; staining charactristics were suggestive of cryptococci. Clinical and radiological improvement was seen after treatment with amphoterecin-B.Disseminated fungal infection should be suspected as a cause of pyrexia of unknown origin after ruling out the commoner causes. Biopsy from enlarged lymph node or organomegaly may yield the diagnosis when non-invasive tests fail.