Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.

Research paper by Ariamala A Gopalsamy, Kitae K Lim, Gregory G Ciszewski, Kaapjoo K Park, John W JW Ellingboe, Jonathan J Bloom, Shabana S Insaf, Janis J Upeslacis, Tarek S TS Mansour, Girija G Krishnamurthy, Murthy M Damarla, Yelena Y Pyatski, Douglas D Ho, Anita Y M AY Howe, Mark M Orlowski, et al.

Indexed on: 14 Dec '04Published on: 14 Dec '04Published in: Journal of Medicinal Chemistry


A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.