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Die Feinstruktur eines Polyomavirus-induzierten Sarkoms der Rattenniere während seines Wachstums

Research paper by A. Georgii, J. Thiele, E. Reale

Indexed on: 01 Dec '73Published on: 01 Dec '73Published in: Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology



Abstract

The fine structure of a SE-polyoma virus-induced sarcoma in the kidney of rats was examined following its growth during 80 days and compared to a tumor of a thymectomized rat and to tissue culture of this sarcoma. The tumor is composed of a single kind of cell that is consistent with a fibroblast because it synthesizes collagen and elastic fibers. The matrix cell of the sarcoma, and consequently the target cell for the polyoma virus, is the interstitial cell of fibroblastic type found in the transitional zone of the kidney. In regard to cell kinetics, it seems important that the sarcoma always exhibits the same monotonous fine structure, independent of the age (20th–102nd day) of the animal, thymectomy, or growth in tissue culture. The quantity of collagenous fibers does increase continuously up to the 40th day. From about the 70th day the absolute number of tumor cells per observation field seems to decrease in favor of the collagen.We were not able to detect polyoma virus-like particles in the nucleolus or cytoplasm. These results definitively exclude that our polyoma-virus strain had a simultaneous productive-cytolytic effect, even in very early sarcoma cells (20th day).