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Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B.

Research paper by Steven M SM Greenberg, Thomas T Grabowski, M Edip ME Gurol, Maureen E ME Skehan, R N Kaveer RN Nandigam, John A JA Becker, Monica M Garcia-Alloza, Claudia C Prada, Matthew P MP Frosch, Jonathan J Rosand, Anand A Viswanathan, Eric E EE Smith, Keith A KA Johnson

Indexed on: 11 Dec '08Published on: 11 Dec '08Published in: Annals of Neurology



Abstract

Imaging of cerebrovascular beta-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar beta-amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions.

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