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Design, synthesis and biological evaluation of simplified side chains of the macrolide antibiotic etnangien.

Research paper by Mario M Altendorfer, Herbert H Irschik, Dirk D Menche

Indexed on: 27 Jul '12Published on: 27 Jul '12Published in: Bioorganic & Medicinal Chemistry Letters



Abstract

Novel simplified side chains of the potent RNA polymerase inhibitor etnangien were designed, synthesized and evaluated for antibacterial activity against Gram-positive bacteria and one Gram-negative bacterium.