Design of a Numbering-up System of Monolithic Microreactors and Its Application to Synthesis of a Key Intermediate of Valsartan

Research paper by Aiichiro Nagaki, Katsuyuki Hirose, Osamu Tonomura, Satoshi Taniguchi, Toshiki Taga, Shinji Hasebe, Norio Ishizuka, Jun-ichi Yoshida

Indexed on: 09 Mar '16Published on: 24 Feb '16Published in: Organic Process Research & Development


Synthesis of a key intermediate of valsartan was accomplished using five parallel monolithic microreactors connected to a split-and-recombine-type flow distributor. The channel resistances of the flow distributor were designed so as to minimize the flow maldistribution among reactors by using pressure drop compartment model, which is analogous to electrical resistance network.

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