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Design, development and characterization of multi-functionalized gold nanoparticles for biodetection and targeted boron delivery in BNCT applications.

Research paper by Subhra S Mandal, Gerald J GJ Bakeine, Silke S Krol, Cinzia C Ferrari, Anna M AM Clerici, Cecilia C Zonta, Laura L Cansolino, Francesca F Ballarini, Silva S Bortolussi, Subrina S Stella, Nicoletta N Protti, Piero P Bruschi, Saverio S Altieri

Indexed on: 07 Jun '11Published on: 07 Jun '11Published in: Applied Radiation and Isotopes



Abstract

The aim of this study is to optimize targeted boron delivery to cancer cells and its tracking down to the cellular level. To this end, we describe the design and synthesis of novel nanovectors that double as targeted boron delivery agents and fluorescent imaging probes. Gold nanoparticles were coated with multilayers of polyelectrolytes functionalized with the fluorescent dye (FITC), boronophenylalanine and folic acid. In vitro confocal fluorescence microscopy demonstrated significant uptake of the nanoparticles in cancer cells that are known to overexpress folate receptors.

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