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Cytoskeletal regulation: coordinating actin and microtubule dynamics in membrane trafficking.

Research paper by Andrea A Disanza, Giorgio G Scita

Indexed on: 25 Sep '08Published on: 25 Sep '08Published in: Current Biology



Abstract

The Arp2/3 complex is essential for actin nucleation and filament elongation in a variety of intracellular processes. This functional versatility is exerted through the regulation of its activity by nucleation-promoting factors (NPFs). The discovery of a new NPF, WHAMM, reveals unexpected connections between the actin and microtubule cytoskeletons and membrane dynamics during ER-to-Golgi transport.