Indexed on: 12 May '05Published on: 12 May '05Published in: Journal of the American Chemical Society
A novel and efficient C-C bond formation method was developed via the cross-dehydrogenative coupling (CDC) reaction of indoles and tetrahydroisoquinolines catalyzed by copper bromide in the presence of an oxidizing reagent, tert-BuOOH. The CDC reaction provides a simple and efficient catalytic method to construct indolyl tetrahydroisoquinolines via a combination of sp3 C-H bond and sp2 C-H bond followed by C-C bond formation.
Indexed on: 26 Jan '17
Published on: 26 Jan '17 in Journal of Organic Chemistry