Correlations of Parameters of Cerebral Evoked Potentials with Age, Clinical, and Social Characteristics of Patients with the First Episode of Psychosis

Research paper by O. I. Osokina, B. B. Ivnyev, V. A. Abramov

Indexed on: 26 Aug '14Published on: 26 Aug '14Published in: Neurophysiology


In 46 patients with the first episode of psychosis (FEP; code number F2 according to DSM-IV), we studied correlations of the parameters of visual and auditory evoked potentials, EPs (amplitudes and latencies of early, P100, N100, and P200, and late, N200, Р300, and N400, EP components), and time of the sensorimotor reaction, SMR, on the one hand, and clinical, pathopsychological, social, demographic, and organizational factors characterizing the course of the disease and personalities of these patients, on the other hand. We found significant correlations of the parameters of waves Р100, Р300, and N400 with the age of the FEP start, duration of its prodromal period, age of the first hospitalization, duration of treatment in a hospital, and level of premorbid functioning. Early beginning of the prodromal FEP period and early age of the first psychotic attack, as well as short-duration treatment, correlated with worsening of the characteristics of memory and associative processes. We conclude that the characteristics of waves N200, N400, and Р300 of visual EPs and the SMR time can be used as markers of the clinical state for positive FEP symptoms, while the parameters of the Р2-N2 complex can be used from this aspect for negative symptoms.