Copper-mediated dehydrogenative biaryl coupling of naphthylamines and 1,3-azoles.

Research paper by Riko R Odani, Koji K Hirano, Tetsuya T Satoh, Masahiro M Miura

Indexed on: 10 Oct '13Published on: 10 Oct '13Published in: Journal of Organic Chemistry


A copper-mediated dehydrogenative biaryl cross-coupling of naphthylamines and 1,3-azoles has been developed. The key to its success is the introduction of N,N-bidentate coordination system based on the picolinamide directing group. The reaction proceeds smoothly without precious transition metal catalysts and provides highly π-extended heterobiaryls directly.