Copper-catalyzed ortho-acylation of phenols with aryl aldehydes and its application in one-step preparation of xanthones.

Research paper by Jun J Hu, Enoch A EA Adogla, Yong Y Ju, Daping D Fan, Qian Q Wang

Indexed on: 17 Oct '12Published on: 17 Oct '12Published in: Chemical Communications


In the presence of triphenylphosphine, copper(II) chloride can catalyze an intermolecular ortho-acylation reaction of phenols with aryl aldehydes. The reaction proceeds smoothly with a wide range of starting materials, and furthermore, it can be used to synthesize xanthone derivatives in a single step in high yields.