Contrast stasis on noncontrast computed tomography as a predictor of stroke postthrombolysis.

Research paper by George M GM Ghobrial, Anil K AK Nair, Richard T RT Dalyai, Pascal P Jabbour, Stavropoula I SI Tjoumakaris, Aaron S AS Dumont, Robert H RH Rosenwasser, L Fernando LF Gonzalez

Indexed on: 03 Jun '11Published on: 03 Jun '11Published in: Neurosurgical focus


Multimodal endovascular intervention is becoming more commonplace for the acute intervention of ischemic stroke. Hyperdensity in a portion of the treated territory is a common finding on postthrombolytic noncontrast CT (NCCT), but its significance is poorly understood. The authors conducted a single-institution, retrospective chart review of patients who had intraarterial thrombolysis of the anterior circulation between 2010 and 2011 with evidence of hyperdensity on NCCT following recanalization. Eighteen patients had evidence of postoperative contrast stasis causing hyperdensity on NCCT. One hundred percent of the patients had MR imaging evidence of completed strokes postoperatively in the same distribution as the stasis. Stasis on NCCT after intervention had a sensitivity and specificity of 82% and 0% for predicting stroke, respectively. Furthermore, the positive predictive value was 100%. The presence of contrast stasis on postthrombolytic NCCT correlates well with stroke seen on subsequent MR imaging.