Indexed on: 12 Feb '20Published on: 10 Feb '20Published in: Ophthalmic research
To identify long-term changes of individual retinal layer thickness using automated layer segmentation analysis on high-resolution spectral optical coherence tomography (SD-OCT) scans in eyes with macula-off rhegmatogenous retinal detachment (RRD) treated with vitreoretinal surgery (VRS) and gas or silicone oil tamponade and having single operation success. 58 patients operated with the VRS for RRD and followed for 12 months were imaged by SD-OCT. The patients with retinal diseases such as an epiretinal membrane, cystic macular edema in the operated and fellow eyes were excluded. The thickness of Retinal Nerve Fiber Layer (RNFL), Ganglion Cell Layer (GCL), Inner Plexiform Layer (IPL), Inner Nuclear Layer (INL), Outer Plexiform Layer (OPL), Outer Nuclear Layer (ONL), Photoreceptor Layer (PR), and Retinal Pigment Epithelium (RPE) were compared to fellow eyes after 12-months follow-up. Thickness changes of individual layers were quantitatively analyzed in operated and fellow eyes and correlated with the type of tamponade used in the surgery. Spectralis OCT automated segmentation software was used for retinal layer analysis. There were 22 female and 36 male. Mean age was 60.7±11.2 years. Central macular thickness was 214.3±29.5µm in the operated and 229.7±21.7µm in the fellow eyes (p=0.008). There was a statistically significant difference between operated and healthy fellow eyes in the following layers; RNFL (p=0.017), GCL (p=0.02), INL (p=0.005) and ONL (p=0.008) in the central foveal area, RNFL (p<0.001), INL (p=0.017) and ONL (p=0.022) in the perifoveal circle, RNFL (p<0.001), IPL (p=0.042), INL (p=0.001) and OPL (p=0.001) in the peripheral circle. LogMAR best-corrected visual acuities were 2.51±0.68 and 2.69±0.62 at baseline and 0.60±0.38 and 0.50±0.38 at month-12 in the silicone (n:28) and gas (n:30) tamponade group (p=0.52 and p=0.21, respectively). Foveal GCL, OPL and ONL, perifoveal GCL and IPL were statistically thinner in the silicone tamponade group (p=0.01, p=0.046, p=0.024, p=0.006, p=0.011 respectively). Significant changes were observed in the retinal layers after the VRS for RRD. Individual retinal layers seem to be affected one-year after the VRS for RRD. The type of tamponade can influence the thickness of the retinal layers. The thickness of retinal layers was preserved significantly in eyes with gas tamponade when compared to silicone tamponade in the long-term. Further studies are needed to validate our results. © 2020 S. Karger AG, Basel.