Combing the Hairball: Improving Visualization of miRNA-Target Interaction Networks.

Research paper by Francesco F Russo, Jessica Xin JX Hu, Jose Alejandro JA Romero Herrera, Søren S Brunak

Indexed on: 12 Apr '19Published on: 10 Apr '19Published in: Methods in molecular biology (Clifton, N.J.)


The visualization of regulatory networks is becoming increasingly important in order to understand molecular mechanisms and diseases. MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) responsible of the post-transcriptional regulation of messenger RNAs (mRNAs) and other ncRNAs. MiRNAs are involved in numerous biological processes including development, cell proliferation, and apoptosis. They are also key molecules in major complex diseases such as cancer and cardiovascular diseases. A single miRNA can regulate many targets, making the analysis and visualization of these complex networks challenging. Here, we present standard and advanced visualization approaches to represent networks with a special focus on miRNA-target interactions.