Combinatorial discovery of fluorophores and fluorescent probes.

Research paper by Nathaniel S NS Finney

Indexed on: 09 May '06Published on: 09 May '06Published in: Current Opinion in Chemical Biology


The properties of organic fluorophores are difficult to predict, even in simple cases. Fluorescent probes--which combine fluorescent properties with the equally challenging problem of molecular recognition--are even more difficult to develop. Combinatorial approaches to the development of such molecules are a new but promising endeavor, and reviewing the state of the art delineates the near-and long-term possibilities.