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Colostrum supplementation protects against exercise-induced oxidative stress in skeletal muscle in mice.

Research paper by Mahenderan M Appukutty, Ammu Kutty AK Radhakrishnan, Kalavathy K Ramasamy, Rajesh R Ramasamy, Abu Bakar AB Abdul Majeed, Mohd Ismail MI Noor, Nik Shanita NS Safii, Poh Bee PB Koon, Karuthan K Chinna, Nagaraja N Haleagrahara

Indexed on: 24 Nov '12Published on: 24 Nov '12Published in: BMC Research Notes



Abstract

This study examined the effects of bovine colostrum on exercise -induced modulation of antioxidant parameters in skeletal muscle in mice. Adult male BALB/c mice were randomly divided into four groups (control, colostrum alone, exercise and exercise with colostrum) and each group had three subgroups (day 0, 21 and 42). Colostrum groups of mice were given a daily oral supplement of 50 mg/kg body weight of bovine colostrum and the exercise group of mice were made to exercise on the treadmill for 30 minutes per day. Total antioxidants, lipid hydroperoxides, xanthine oxidase and super oxide dismutase level was assayed from the homogenate of hind limb skeletal muscle.Exercise-induced a significant oxidative stress in skeletal muscles as evidenced by the elevated lipid hydroperoxides and xanthine oxidase levels. There was a significant decrease in skeletal muscle total antioxidants and superoxide dismutase levels. Daily colostrum supplement significantly reduced the lipid hydroperoxides and xanthine oxidase enzyme level and increased the total antioxidant levels in the leg muscle.Thus, the findings of this study showed that daily bovine colostrum supplementation was beneficial to skeletal muscle to reduce the oxidant-induced damage during muscular exercise.