Clusterin is associated with spontaneous breast cancer in TA2 mice.

Research paper by Baocun B Sun, Shiwu S Zhang, Danfang D Zhang, Yanqing Y Liu, Yan Y Li, Zhe Z Rong, Yue Y Zhu, Xinghong X Jia

Indexed on: 29 Jun '07Published on: 29 Jun '07Published in: FEBS Letters


Two-dimensional electrophoresis and Matrix-assisted laser desorption ionization-time of flight-time of mass spectrometry were used to detect the differentially expressed proteins in serum of tientsin albinao 2 mice with spontaneous breast cancer, normal tientsin albinao 2 mice and tientsin albinao 1 mice. Only nuclear clusterin (n-CLU) was expressed in tientsin albinao 1. Immunohistochemistry and western blot validated that n-CLU was present in normal tientsin albinao 2 and tientsin albinao 1 mammary epithelium, and secretory clusterin expressed in the cytoplasm of normal tientsin albinao 2 mammary epithelium and spontaneous breast cancer. n-CLU may play an important role in tientsin albinao 2 spontaneous breast cancer initiation and development.