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Circulating Tumor Markers: Harmonizing the yin and yang of CTCs and ctDNA for precision medicine.

Research paper by I S IS Batth, A A Mitra, S S Manier, I M IM Ghobrial, D D Menter, S S Kopetz, S S Li

Published on: 22 Dec '16Published in: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO

Abstract

Current trajectory of clinical care is heading in the direction of personalized medicine. In an ideal scenario, clinicians can obtain extensive diagnostic and prognostic information via minimallyinvasive assays. Information available in the peripheral blood has the potential to bring us closer to this goal. In this review we highlight the contributions of circulating tumor cells (CTCs) and circulating tumor DNA and RNA (ctDNA/ctRNA) towards cancer therapeutic field. We discuss clinical relevance, summarize available and upcoming technologies, and hypothesize how future care could be impacted by a combined study.