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Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice.

Research paper by Tim T De Schutter, Graciela G Andrei, Dimitri D Topalis, Sophie S Duraffour, Tania T Mitera, Lieve L Naesens, Joost J van den Oord, Patrick P Matthys, Robert R Snoeck

Indexed on: 13 Nov '12Published on: 13 Nov '12Published in: Cancer Letters



Abstract

Cidofovir has shown antiproliferative effects against human papillomavirus (HPV)-positive cells and successfully suppressed the growth of HPV-positive xenografts in athymic nude mice. The present study evaluated the effect of cidofovir on several disease parameters in this animal model. Intratumoral administration of cidofovir resulted in a beneficial effect on body weight gain, a reduction in splenomegaly, a partial restoration of tryptophan catabolism, and diminished the inflammatory state induced by the xenografts. Administration of cidofovir to tumor-free animals did not have a direct effect on these parameters. Beyond suppressing tumor growth, intratumoral treatment with cidofovir ameliorated the pathology associated with HPV-tumor growth.