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Characterization of a novel HLA-DRB1*04 allele (DRB1*0460) in the Italian population.

Research paper by S S Frison, C C Rinaldini, M M Pagoda, C C Brambilla, F F Poli

Indexed on: 08 Feb '07Published on: 08 Feb '07Published in: International Journal of Immunogenetics



Abstract

We report the identification of a novel HLA-DRB1*04, officially named DRB1*0460. It was detected during performing HLA-DRB1 high resolution typing by DNA sequencing-based method. The exon 2 nucleotide sequence of DRB1*0460 is identical to that of DRB1*040301 except at codon 63 (AGC-->AAC), changing the encoded serine to asparagine.