Changes in nonspecific lymphoid (NK, K, T cell) cytotoxicity following BCG immunisation of healthy subjects

Research paper by N. Thatcher, D. Crowther

Indexed on: 01 Dec '78Published on: 01 Dec '78Published in: Cancer Immunology, Immunotherapy


Nonspecific cytotoxicity was investigated in five healthy subjects following a single BCG immunisation (day 0). A decline in white cell, lymphocyte, and monocyte counts occurred at day 2, followed by increases back to baseline levels. Lymphoid NK, K, and to a lesser extent T cell cytotoxicity exhibited a similar pattern in the five subjects; a decrease at day 2, followed by recovery by day 7. An overshoot on days 10 and 14 for NK cytotoxicity was then observed, with ADCC activity still significantly increased at day 21. A decline towards baseline values was seen at day 28. The implications for immunotherapy scheduling are discussed.