Cerebellar Cognitive Affective Syndrome Improved by Donepezil.

Research paper by Yoichiro Y Nishida, Masaki M Hizume, Yuichi Y Fumimura, Tadashi T Ichikawa

Indexed on: 21 Dec '18Published on: 21 Dec '18Published in: Internal medicine (Tokyo, Japan)


Cerebellar damage can cause not only disturbance in motor control but also higher brain dysfunction known as cerebellar cognitive affective syndrome (CCAS). Although CCAS has a high prevalence, the precise mechanism and effective medications are unknown. We herein report a CCAS patient whose symptoms were ameliorated with the cholinesterase inhibitor donepezil. N-isopropyl-p-I-iodoamphetamine-single-photon emission computed tomography showed improvement in hypoperfusion in the contralateral frontal and parieto-temporal lobes. Some projections with cholinergic transmission might form a functional connectivity between the cerebellum and contralateral association cortices, and cholinergic dysfunction is involved in CCAS pathophysiology. Donepezil might be worth considering for some CCAS patients.