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Cells of the synovium in rheumatoid arthritis. T lymphocytes.

Research paper by Steven K SK Lundy, Sujata S Sarkar, Laura A LA Tesmer, David A DA Fox

Indexed on: 20 Feb '07Published on: 20 Feb '07Published in: Arthritis Research & Therapy



Abstract

Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition, spontaneous animal models of arthritis, and cell-cell interactions that implicate T cells as driving synovial inflammation and joint destruction. Information regarding the proinflammatory role of interleukin-17-producing T cells and the functional state of regulatory T cells both in animal models and in patients with RA is also discussed. In light of the overwhelming evidence that disrupted T-cell homeostasis greatly contributes to joint pathology in RA, the therapeutic potential of targeting activators of pro-inflammatory T cells or their products is compelling.