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Cell-mediated tumour immunity in patients with transitional cell carcinoma of the urinary bladder

Research paper by J. Bubeník

Indexed on: 01 Dec '75Published on: 01 Dec '75Published in: International Urology and Nephrology



Abstract

Some recent data on problems of cell-mediated immune reaction directed against tumour-associated antigens (TAA) of transitional cell carcinomas of the urinary bladder (BTCC) are reviewed. All of the 13 samples of BTCC examined in our laboratory using a lymphocytotoxicity microassay contained the characteristic TAA of urinary bladder carcinomas. TAA were absent in 14 control tissue samples. Forty-seven out of 70 (67%) patients with BTCC developed cytotoxic lymphocytes reacting, with BTCC cells. However, cytotoxic lymphocytes were also found in the blood of 8 out of 165 (4.8%) control lymphocyte donors.