Care-by-parent model as a tool for reduction in neonatal opioid withdrawal syndrome in neonates exposed to buprenorphine maintenance therapy in-utero.

Research paper by Megan L ML Lawlor, Lori L Shook, Kristen K McQuerry, Aarthi A Srinivasan, Quinetta B QB Johnson, Niraj R NR Chavan, Agatha S AS Critchfield

Indexed on: 20 Dec '18Published on: 20 Dec '18Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians


To determine if a structured care-by-parent (CBP) protocol is associated with a reduction in diagnosis of treatment-requiring Neonatal Opioid Withdrawal Syndrome (NOWS). We performed a pilot retrospective, case control study of pregnant women enrolled in a comprehensive prenatal care program for opioid-dependent patients during which they received buprenorphine for Medication Assisted Treatment (MAT) for Opioid Use Disorder (OUD). Patients who participated in the care-by-parent (CBP) program actively roomed-in with their infants even after maternal hospital discharge while infants continued to be monitored for development of treatment-requiring Neonatal Opioid Withdrawal Syndrome (NOWS). The primary outcome was the rate of treatment-requiring NOWS in the CBP grouping. Thirty-two [32] cases who were enrolled in the CBP model were compared with 32 matched controls who were not enrolled in this model. There was a significant reduction in the rate of treatment-requiring NOWS among cases compared to the controls (OR 0.10; p = 0.0012). Neonates undergoing CBP had a decreased length of stay and lower Finnegan scores compared to those who did not undergo CBP Conclusion: Among infants born to mothers with OUD in pregnancy, CBP significantly reduces the rate of treatment-requiring NOWS.