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Carbon radical attack on a pyrimidine nitrogen. An unusual entry into polycyclic aminopyrimidones.

Research paper by Ling L Qin, Zhibo Z Liu, Samir Z SZ Zard

Indexed on: 16 May '14Published on: 16 May '14Published in: Organic Letters



Abstract

Unprecedented examples of a synthetically useful radical ring closure onto a pyrimidine nitrogen leading to novel, highly functionalized bi- and tricyclic pyrimidone structures are reported. An unexpected hydrogen atom translocation prior to the cyclization step was observed in some cases.