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Capacitive biosensors for ultra-sensitive assays

Research paper by Bo Mattiasson, Martin Hedström

Indexed on: 14 Mar '16Published on: 21 Dec '15Published in: Trends in Analytical Chemistry



Abstract

Capacitive binding assays have for long been regarded as potentially very sensitive. The technique of sending short potential pulses and then registering the current has been the basis for such assays. However, with the introduction of current pulses and registration of potential responses, a dramatic improvement in stability was gained, which formed the basis for assays of extreme sensitivities. The new assaying technology has been applied in a range of different affinity binding assays, from immuno- via DNA-base pairing to the use of molecularly imprinting polymers (MIPs). Overall, very good sensitivities are recorded and for the MIPs also high stability and reusability.

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