Indexed on: 20 Dec '18Published on: 20 Dec '18Published in: Marine drugs
Two new sceptrin derivatives (,) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge . By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin () and ageleste C (), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds and also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.