Bromopyrrole Alkaloids from the Sponge Agelas kosrae.

Research paper by Oh-Seok OS Kwon, Donghwa D Kim, Heegyu H Kim, Yeon-Ju YJ Lee, Hyi-Seung HS Lee, Chung J CJ Sim, Dong-Chan DC Oh, Sang Kook SK Lee, Ki-Bong KB Oh, Jongheon J Shin

Indexed on: 20 Dec '18Published on: 20 Dec '18Published in: Marine drugs


Two new sceptrin derivatives (,) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge . By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin () and ageleste C (), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds and also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.