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Bioactive metabolites from cultures of basidiomycete Favolaschia tonkinensis.

Research paper by Jittra J Kornsakulkarn, Chawanee C Thongpanchang, Rittikorn R Chainoy, Wilunda W Choowong, Sutichai S Nithithanasilp, Tienthong T Thongpanchang

Indexed on: 25 Mar '10Published on: 25 Mar '10Published in: Journal of Natural Products



Abstract

Two strobilurins, 9-methoxystrobilurin B (1) and 9-methoxystrobilurin G (2), two monochlorinated 2,3-dihydro-1-benzoxepin derivatives, 3 and 4a, and butenolide 5, together with four known compounds, strobilurin B, 9-methoxystrobilurin A, and oudemansins A and B, were isolated from culture BCC 18689 of the fungus Favolaschia tonkinensis. 9-Methoxystrobilurins A, B (1), and G (2) and oudemansins A and B exhibited antimalarial, antifungal, and cytotoxic activities, while compounds 3, 4a, and 5 displayed only cytotoxic activity.

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