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Aureolic acids: similar antibiotics with different biosynthetic gene clusters.

Research paper by Sarah S O'Connor

Indexed on: 29 Apr '04Published on: 29 Apr '04Published in: Chemistry & Biology



Abstract

In this issue of Chemistry & Biology, Méndez and colleagues describe the sequence and organization of the chromomycin gene cluster. Unexpectedly, the arrangement is starkly different from the mithramycin biosynthetic cluster, despite similarity in the individual genes and the near identical structures of the two antibiotic aureolic acids.