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AuNPs as an important inorganic nanoparticle applied in drug carrier systems.

Research paper by Wen W Li, Zhiwen Z Cao, Rui R Liu, Linlin L Liu, Hui H Li, Xiang X Li, Youwen Y Chen, Cheng C Lu, Yuanyan Y Liu

Indexed on: 22 Nov '19Published on: 13 Nov '19Published in: Artificial cells, nanomedicine, and biotechnology



Abstract

Gold nanoparticles (AuNPs), as a kind of inorganic nanoparticle, have been gradually recognized as one of the most promising nanomaterials, which is attributed to their unique optical, electronic, sensing and biochemical characteristics. Due to such unique characteristics, AuNPs have been widely applied in biomedical fields such as diagnosis, biosensing and drug delivery. Except for their use in cancer treatment alone with their photothermal ablation of solid tumours, when used with anticancer drugs, AuNPs can exert a dual role in treating cancer. With the advantages of protecting drugs from degradation and leakage in the physiological environment, tuneable modification in size, surface and shape, and biocompatibility, AuNPs can be used as promising drug carriers in anticancer drug design. However, there are still many aspects that need to be improved during the usage of drug carriers in pharmacology including the following aspects: prolongation in the plasma, enhancement in targeting accumulation, improvement in cellular uptake and the control of intracellular release. AuNPs are important drug carriers.