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Asymmetric organocatalytic Michael addition of ketones to vinyl sulfone.

Research paper by Qiang Q Zhu, Lili L Cheng, Yixin Y Lu

Indexed on: 03 Dec '08Published on: 03 Dec '08Published in: Chemical Communications



Abstract

Highly enantioselective organocatalytic Michael addition of ketones to vinyl sulfone catalyzed by a cinchona alkaloid-derived primary amine is reported for the first time; the described synthetic methodology was applied to the synthesis of sodium cyclamate.