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Asymmetric epoxidation of α,β-unsaturated ketones using α,α-diarylprolinols as catalysts

Research paper by ChangWu Zheng, Gang Zhao

Indexed on: 18 Jun '10Published on: 18 Jun '10Published in: Chinese science bulletin = Kexue tongbao



Abstract

Asymmetric epoxidation of α,β-unsaturated ketones has been extensively studied and several important procedures have been developed in the last decade. This review addresses the most significant advances in asymmetric epoxidation of α,β-unsaturated ketones using proline-derived α,α-diarylprolinols as catalysts. Special attention has been paid to the enantioselective epoxidation of chalcones, α,β-unsaturated trifluoromethyl, trichloromethyl ketones and β,γ-unsaturated α-keto esters based on the reseach of our group.